Minimal Change Nephrotic Syndrome After Apitoxin Therapy: A Case Report / 대한신장학회지

Bee stings have previously been implicated in the development of nephrotic syndrome, but the reported cases in the literature are rare. Furthermore, there has been no case of nephrotic syndrome after bee venom (apitoxin) therapy. We experienced a 28-year-old female who developed generalized edema 6 days after an intramuscular injection of apitoxin. The physical examination and laboratory findings were relevant with nephrotic syndrome and the renal biopsy revealed minimal change nephrotic syndrome. The corticosteroid treatment induced prompt remission with resolution of edema and normalization of the laboratory findings. There was no relapse of the disease during the 6-month follow-up. We report this case together with brief review of literatures.

Pneumatosis Cystoides Intestinalis With Portal Venous Gas: Two Case Reports

Pneumatosis cystoides intestinalis is a rare condition which is characterized by multiple gas-filled cysts of varying sizes in the wall of the gastrointestinal tract. In 85% of the cases, it is associated with gastrointestinal, pulmonary, and connective tissue diseases or with other conditions. In about 15% of the cases, the etiology remains obscure. In most cases, the prognosis is poor, so early diagnosis and treatment are required. We report two cases of primary pneumatosis cystoides intestinalis with portal venous gas which were associated with alcoholism and diabetes mellites and which were complicated by pneumoperitoneum and panperitonitis.

Deep Neck Infection due to Severe Neutropenia induced by Terbinafine in a Patient with Systemic Lupus Erythematosus / 대한류마티스학회지

Terbinafine, a fungicidal agent used for the treatment of onychomycosis, has been found to be safe and adverse effects are usually mild and transient. Neutropenia is a rare side effect of terbinafine. Terbinafine-induced neutropenia have been reported 7 cases worldwide and these patients had no predisposing factors that give rise to developing neutropenia. To date there has not been reported in Korea. We report a case of systemic lupus erythematosus of 47-yearold female patient who developed deep neck infection requiring intravenous antibiotics, tracheostomy, granulocyte colony-stimulating factor(G-CSF) to recover from terbinafine-induced neutropenia.

A Case of Sjogren's Syndrome with Interstitial Lung Disease and Multiple Cystic Lung Disease / 결핵

A 47-years-old woman presented with a 2-month history of a dry mouth and dry cough. The patient had been taking medication for Sjogren's syndrome for approximately 7 years. The chest radiography showed multiple cystic lesions and a hazy density in both lower lung fields. The HRCT showed a diffuse ground glass like appearance and multiple variable sized cystic lesions in both lung fields. After medication, the symptoms were aggravated. Bronchoscopy was preformed with a transbronchial lung biopsy. The biopsies showed an infiltration of lymphocytes, neutrophils, monocytes and histiocytes through the interstitial space of the alveola and a widening of the alveolar septa. However, the histological findings of the cysts were not obtained. Sjogren's syndrome is a slowly progressive inflammatory autoimmune disease, which is characterized by lymphocyte mediated destruction of the exocrine glands, with pulmonary involvement in approximately 19-65%, High-resolution CT is a sensitive technique for assessing the pulmonary involvement in patients with Sjogren's syndrome. Although a lung biopsy is not always necessary for establishing a diagnosis of an interstitial lung disease in Sjogren's syndrome. A lung biopsy may reveal a wide spectrum of changes ranging from a mild inflammatory response to end stage fibrosis with honeycombing. Because of the predominantly peribronchiolar inflammatory infiltration and inspissated secretions the cysts were suspected to have been formed by the ballvalve phenomenon. However, no definite evidence was obtained.

A Case of Nephrotic Syndrome Associated with Total Hydatidiform Mole / 대한신장학회잡지

A case study and review of nephrotic syndrome associated with a total Hydatidiform mole in 54- year-old female is presented. She has generalized edema, nephrotic range proteinuria(8.05gm/day), hypoalbuminemia(2.5g/dl) and high serum level of beta- hCG(200,000IU/L). Radiological investigations showed a 16-cm sized heterogenous enhanced mass in the uterus. A renal biopsy performed before evacuation of H-mole showed a focal segmental glomerulosclerosis. The complete remission of symptoms and signs of the nephrotic syndrom after evacuation of a molar tissue was achieved. A review of the literature revealed that this patient appears to be the first case of the FSGS with nephrotic syndrome associated with a total mole that remitted completely after the mole evacuation.